Senior Scientist, Immuno-Oncology Discovery

Waltham, Massachusetts

This job has expired.

Senior Scientist, Immuno-Oncology Discovery

Location: Waltham, MA

What Is Happening at AstraZeneca

At AstraZeneca, we work together across global boundaries to make an impact and find answers to challenges. We do this with the utmost integrity even in the most difficult situations because we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways, combining our people's exceptional skills with those of people from all over the globe. We turn ideas into life changing medicines. Working here means being ambitious, thinking big and working together to make the impossible a reality.

About Our Waltham Oncology Hub

Our Waltham, Massachusetts facility creates life-changing medicines for people around the world. This campus employs experts in our field and is only a short drive from Boston and Cambridge, MA. Here, we host some of the most pioneering technology and lab spaces, all designed to inspire collaboration and cross-functional science. We are dedicated to creating a culture of inclusion and collaboration.

The Waltham site offers a variety of amenities to help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria, community garden, and much more. This is where you'll find newly designed, activity-based workspaces to suit a variety of working styles while growing collaboration between teams.

Main Duties and Responsibilities

AstraZeneca seeks an innovative and highly motivated Senior Scientist with a background in immunology to join the Immuno-Oncology Discovery team in Waltham, MA. As a Senior Scientist you will be a key member of a team focused on supporting Immuno-Oncology projects through the drug discovery process. You will bring your expertise in Immunology to establish assay systems and deliver datasets that will have direct impact on pipeline programs.

Working in this laboratory-based position within the Immune Cell Circuits and Engagers group you will develop, conduct and analyze experiments to assess the function of our candidate drugs. You will design novel therapeutics targeting the immune system for cancer therapy and help to dissect their mechanism of action. You will be expected to support cross-functional teams and work collaboratively with colleagues to ensure the timely generation and dissemination of critical program data. You will also review emerging literature and internal data to help in identifying new potential targets and contribute to target validation activities.

A solid foundation in immunology and T cell biology with experience in different in vitro and in vivo assays (including mouse models) for the evaluation of immune cell function is essential for this role. Equally important is your broad interest in immunological axes being leveraged therapeutically against cancer. As a highly organized, self-motivated individual with a strong lab/practical background you will stay up to date with relevant techniques and have a genuine passion for this field of research. The position requires strong interest in experimental work and ability to work in a fast-paced matrix structured work environment.

Essential Requirements

  • A PhD in immunology and/or immuno-oncology, with 0-6 years of post-doctoral experience, or MSc with appropriate industry experience, in a relevant research area.
  • Strong background in immunology and experience performing standard in vitro assays (immune cell activation, cytotoxic assays, etc) and use of in vivo mouse models.
  • Expertise with multi-color flow cytometry to evaluate leukocyte populations and function.
  • Ability to independently design and execute research plans for one or more programs, and to review, analyse, and interpret experimental results rapidly.
  • Ability to draft, execute and record protocols and experiments in a timely manner and maintain an excellent laboratory notebook.
  • Job complexity is high and requires the ability to work with high degree of independence as well of a sense of urgency.
  • Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment.
  • Proven track record of success in your research and experience preparing written scientific reports and oral presentations.
AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.

AstraZeneca requires all US employees to be fully vaccinated for COVID-19 but will consider requests for reasonable accommodations as required by applicable law.

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