Director / Associate Director Clinical Pharmacometrician
AstraZeneca

Director / Associate Director Clinical Pharmacometrician

Do you have great expertise and experience in mathematical/statistical modelling and simulation, PKPD and its application in drug development? Would you like to apply your knowledge in a company that is following the science and turn ideas into life changing medicines? Then this might be your next challenge!

This is an opportunity for a skilled and engaged individual to join our growing Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca in Gaithersburg (Maryland, US) and contribute as a Director / Associate Director Clinical Pharmacometrician supporting large and small molecule projects across all phases of clinical drug development within the therapy area of Cardiovascular, Renal and Metabolism.

Within AstraZeneca, we have a state-of-the-art quantitative CPQP organization with a diverse and uniquely skilled team of clinical pharmacometricians, clinical pharmacology scientists and other specialists. You will thrive in an environment that inspires innovation, encourages multidisciplinary team-working and collaboration with academia, and rewards original scientific thinking.

What you will do:
Working closely with clinical pharmacologist, physicians, statisticians and other scientists, you will apply model informed drug development (MIDD) to contribute to clinical programs, to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.

The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Use of simulations and informative pharmacometric/statistical analyses to inform trial and program designs and decisions are important focus areas for us.

In collaboration with clinical pharmacologists, you will represent CPQP in cross-functional clinical project teams and be responsible for identifying and executing model informed drug development to accelerate and inform decision making. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals.

The seniority of the role can depend and be adjusted according to your previous experience and skills.

Requirement:

• PhD or equivalent (M.Sc. or Pharm.D.) with relevant experience in quantitative modelling , e.g. knowledge in mathematics and statistics applied to life sciences
  
• Experience in combined industry and/or regulatory postdoctoral experience in the field of quantitative modelling
  
• The seniority of the role can depend and be adjusted according to your previous experience and skills (3-6 years Associate Director level, 6+ years Director level)
  
• Strong background in, and an understanding of clinical pharmacology aspects of drug development, preferably in both a small and large molecule setting
  
• Good knowledge of pharmacokinetics, PKPD and its clinical applications
  
• Biological understanding of disease and drug action
  

Desirable in the role:

• Track record in creating and delivering on MIDD strategies in clinical drug development programs for both small and large molecules
  
• Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacology
  
• Early or late phase clinical development experience
  

We truly believe that everyone contributes with a unique set of competence. Your curiosity and passion for personal development combined with support from colleagues, mentors and leaders, will ensure you maximise your skills, abilities and contribution. You have a real passion for your subject, along with a collaborative nature and ability to work in multi-disciplinary global teams.

Why AstraZeneca?

We are a global, science-led BioPharmaceutical business and our innovative medicines are used by millions of patients worldwide. Collaborate in an inclusive environment, a place full of bold new opportunities. Be empowered to be innovative and creative where difference is valued.

So, what's next? If the sounds like the job and place for you - apply today!

For more information about the position please contact the hiring manager, Anis Khan (https://www.linkedin.com/in/anis-khan-4a63a72/).

Additional information:
Follow AstraZeneca on LinkedIn: https://www.linkedin.com/company/1603/
Follow AstraZeneca on Instagram: https://www.instagram.com/astrazeneca_careers/?hl=en

About BioPharmaceuticals R&D: https://www.astrazeneca.com/r-d.html

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