Principal Research Associate, Nucleic Acid Technologies
ModernaTX, Inc.

The Role:

Moderna's Bioanalytics team is looking for Principal Research Associate with strong hands-on experiences in bioanalytical RT-qPCR/qPCR . The individual should have recent experiences in processing and analysis of wide range of molecules such as proteins, peptides, lipids, glycans, mRNA etc. The role will be supporting method development for non-clinical studies of development candidates applying cutting-edge RT-qPCR/qPCR/ddPCR techniques towards mechanistic and quantitative assessment of Moderna's mRNA therapeutics. The candidate must thrive in scientifically stimulating and fast paced environment with high expectations. Independent method development, data integrity, ability to troubleshoot, collaborate with cross functional teams, respect for peers/colleagues, excellent work ethic and setting the bar high are key values to thrive in our Team.

The candidate must thrive in a fast pace environment with high expectations. Integrity, quality, ability to troubleshoot issues, creative, bold, curiosity, collaborative spirit, respect for people, exemplary work ethic and setting the bar high are key values to thrive in our Team.

Here's What You'll Do:

• Method development, method optimization, fit-for-purpose qualification to support all Therapeutic Programs
  
• Develop, optimize, qualify, and run bioanalytical RT-qPCR/qPCR/ddPCR methods for quantitation of various mRNA in drug products.
  
• Coordinate with external CROs on method development and qualification
  
• Perform method transfer to internal and external stakeholders for qualification / validation
  
• Review and author relevant protocols, and reports
  
• Support nonclinical in-vivo studies to evaluate PK/TK, safety, and efficacy of Moderna's drug candidates
  
• Work closely with colleagues in clinical development organization as well as other cross-functional groups
  
• Mentor/coach junior staff on qPCR/RT-qPCR/ddPCR based methodologies.
  
• Provide RT-qPCR support to scientists in Nonclinical, Platform, and other groups
  

Here's What You'll Bring to the Table:

• MS 2-5 / BS 5-8 years of relevant industry experience
  
• (Preferred) At least 3 years of demonstrated hands-on experience in method development and qualification using qPCR/RT-qPCR/ddPCR in industrial setting.
  
• (Preferred) Expertise in using QS-5, QS-7, Maxwell, Tape station and other relevant instruments
  
• (preferred) Prior experience with method qualification or fit- for-purpose qualification to support method transfer for validation
  
• Hands on experience in cell culture, electrophoresis, PCR, DNA/RNA extraction using variety of biological samples
  
• Solid understanding of drug development process and general overview of mRNA technology
  
• Intermediate statistical knowledge to effectively support bioanalytical method qualification and validation
  
• Understanding of FDA/EMA guidelines on assay development, qualification, and validation
  
• Good project management, organization, and attention to detail; ability to handle multiple projects in a fast-paced environment
  
• Willingness to learn new concepts and challenge boundaries; adaptability to change
  
• Strong interpersonal skills with an eagerness to work with and support colleagues in other departments
  
• Experience in working with CROs and oversee method development/qualification as needed
  

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

• Highly competitive and inclusive medical, dental and vision coverage options
• Flexible Spending Accounts for medical expenses and dependent care expenses
• Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
• Family care benefits, including subsidized back-up care options and on-demand tutoring
• Free premium access to fitness, nutrition, and mindfulness classes
• Exclusive preferred pricing on Peloton fitness equipment
• Adoption and family-planning benefits
• Dedicated care coordination support for our LGBTQ+ community
• Generous paid time off, including:
  • Vacation, sick time and holidays
  • Volunteer time to participate within your community
  • Discretionary winter shut down
  • Paid sabbatical after 5 years; every 3 years thereafter
• Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
• 401k match and Financial Planning tools
• Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
• Complimentary concierge service including home services research, travel booking, and entertainment requests
• Free parking or subsidized commuter passes
• Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
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